人类胰岛素基因序列。

Sequence of the human insulin gene.

作者信息

Bell G I, Pictet R L, Rutter W J, Cordell B, Tischer E, Goodman H M

出版信息

Nature. 1980 Mar 6;284(5751):26-32. doi: 10.1038/284026a0.

Abstract

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.

摘要

人类胰岛素基因包含两个间隔序列，一个在转录成mRNA的5'-非翻译区的区域内，另一个中断C肽编码区。将人类胰岛素基因与大鼠胰岛素基因进行比较，表明该基因之前的DNA片段中存在潜在的调控区域，并提示胰岛素基因的原始形式有两个间隔序列。