Liapina L A, Zhitnikova E S, Kudriashov B A
Farmakol Toksikol. 1978 Jan-Feb;41(1):82-5.
It is shown that the epinephrine-heparin-fibrinogen complex, as well as a number of other complex compounds of heparin accomplish the prophylaxis of thrombogenesis at the initial stages of the process, the epinephrine-heparin-fibrinogen complex lysing the thrombi in an average of 48 minutes, while the complexes of fibrinogen-heparin and epinephrine-heparin do this in 2--4 hours. The complex heparin compounds exercise a thrombolytic action only on non-stabilized fresh thrombi with less than 15 minutes from the time of their formation.
结果表明,肾上腺素-肝素-纤维蛋白原复合物以及肝素的许多其他复合化合物在血栓形成过程的初始阶段起到预防血栓形成的作用,肾上腺素-肝素-纤维蛋白原复合物平均在48分钟内溶解血栓,而纤维蛋白原-肝素复合物和肾上腺素-肝素复合物则在2至4小时内溶解血栓。复合肝素化合物仅对形成时间少于15分钟的不稳定新鲜血栓起溶栓作用。