磷脂酰胆碱与胆固醇二元混合物的动态特性

Dynamic properties of binary mixtures of phosphatidylcholines and cholesterol.

作者信息

Rubenstein J L, Owicki J C, McConnell H M

出版信息

Biochemistry. 1980 Feb 5;19(3):569-73. doi: 10.1021/bi00544a027.

Abstract

We have observed the paramagnetic resonance spectra of a head group spin-labeled phosphatidylethanolamine (L-alpha-dipalmitoylphosphatidyl-N-ethanolamine) as a function of temperature and cholesterol concentration in binary mixtures of cholesterol and dimyristoylphosphatidylcholine. These spectra bear on two interrelated topics involving mixtures of phosphatidylcholine and cholesterol: (1) lipid phase equilibria and the lateral ordering and diffusion of lipid molecules and (2) model membrane immunochemistry using spin-label lipid haptens.

摘要

我们观察了头部基团自旋标记的磷脂酰乙醇胺（L-α-二棕榈酰磷脂酰-N-乙醇胺）在胆固醇与二肉豆蔻酰磷脂酰胆碱的二元混合物中的顺磁共振光谱，该光谱是温度和胆固醇浓度的函数。这些光谱涉及磷脂酰胆碱和胆固醇混合物的两个相互关联的主题：（1）脂质相平衡以及脂质分子的侧向排列和扩散；（2）使用自旋标记脂质半抗原的模型膜免疫化学。