与膜筏研究相关的脂质混合物相图。
Phase diagrams of lipid mixtures relevant to the study of membrane rafts.
作者信息
Goñi Félix M, Alonso Alicia, Bagatolli Luis A, Brown Rhoderick E, Marsh Derek, Prieto Manuel, Thewalt Jenifer L
机构信息
Unidad de Biofísica (Centro Mixto CSIC-UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, P.O. Box 644, 48080 Bilbao, Spain.
出版信息
Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):665-84. doi: 10.1016/j.bbalip.2008.09.002. Epub 2008 Oct 7.
Abstract
The present paper reviews the phase properties of phosphatidylcholine-sphingomyelin-cholesterol mixtures, that are often used as models for membrane "raft" microdomains. The available data based on X-ray, microscopic and spectroscopic observations, surface pressure and calorimetric measurements, and detergent solubilization assays, are critically evaluated and rationalized in terms of triangular phase diagrams. The remaining uncertainties are discussed specifically and separately from the data on which a consensus appears to exist.
摘要
本文综述了磷脂酰胆碱-鞘磷脂-胆固醇混合物的相性质，这些混合物常被用作膜“筏”微区的模型。基于X射线、显微镜和光谱观察、表面压力和量热测量以及去污剂增溶分析的现有数据，根据三角相图进行了严格评估并合理化。具体讨论了剩余的不确定性，并将其与似乎已达成共识的数据分开。
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本文引用的文献
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Phosphatidylcholine: cholesterol phase diagrams.磷脂酰胆碱：胆固醇相图。
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Cholesterol perturbs lipid bilayers nonuniversally.胆固醇对脂质双层的影响并非普遍存在。
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Liquid-liquid domains in bilayers detected by wide angle X-ray scattering.通过广角X射线散射检测到的双层膜中的液-液区域。
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Docosahexaenoic acid enhances segregation of lipids between : 2H-NMR study.二十二碳六烯酸增强脂质间的分离：2H-核磁共振研究
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Small-angle neutron scattering to detect rafts and lipid domains.用于检测筏和脂质结构域的小角中子散射。
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Using monomolecular films to characterize lipid lateral interactions.使用单分子膜来表征脂质侧向相互作用。
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Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers.调整脂质混合物以诱导或抑制无支撑不对称双层膜小叶间的结构域形成。
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Sphingomyelin/phosphatidylcholine and cholesterol interactions studied by imaging mass spectrometry.通过成像质谱法研究鞘磷脂/磷脂酰胆碱与胆固醇的相互作用
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