Bykov N P, Ronin M Ia, Strelkov R B
Farmakol Toksikol. 1978 Jan-Feb;41(1):97-101.
When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.
当以100毫克/千克的剂量使用时，谷胱甘肽α-酮戊二酸在低气压和常气压缺氧性缺氧中发挥显著的抗缺氧作用（将白化小鼠在压力舱中“提升”到10000米的“高度”，气压降至198.7毫米汞柱，PO2为42毫米汞柱，舱内气氛含5.4%体积的氧气，动物置于含5%氧气和95%氮气的密封舱中，气压为760毫米汞柱）。该药物与氧气对运动性缺氧（负重为体重10%的游泳试验）均无抗缺氧作用，这证明这两种缺氧形式的发病机制不同。由此推断，该药物的保护作用可能与机体氧循环的纠正有关。
