Pichugin V V, Grimova T A, Bobrovskaia T O, Gatsura V V
Farmakol Toksikol. 1976 Nov-Dec;39(6):684-7.
Experiments proved gutimine capable of intensify the collateral coronary circulation, intraventricular pressure and the rate of its accretion (dp/dt), the excitability and permeability of the heart, as well as to raise the cardiac contractility in dogs during an acute period of myocardial ischemia. In rats with pituitrin-isadrine induced cardiopathy the drug drastically depressed the permeability of the histohematogenous barriers of the myocardium and lengthened somewhat the life span of the animals. Parallel with is rising doses gutimine depressed the excitability threshold of the frog's heart "in situ" in a test with a liminal current producing extrasystole.
实验证明，胍乙啶能够增强犬在急性心肌缺血期的冠状动脉侧支循环、心室内压及其上升速率（dp/dt）、心脏的兴奋性和通透性，并提高心脏收缩力。在垂体后叶素 - 异丙肾上腺素诱发的大鼠心脏病模型中，该药物可显著降低心肌组织血源性屏障的通透性，并略微延长动物的寿命。随着胍乙啶剂量的增加，在以阈下电流诱发蛙心“原位”期外收缩的试验中，它会降低蛙心的兴奋阈值。
