Uehling D T
Fertil Steril. 1978 Feb;29(2):220-1. doi: 10.1016/s0015-0282(16)43104-3.
Thirty-eight males with idiopathic infertility were randomly treated with low-dose thyroid and low-dose cortisone. Pregnancy followed treatment with cortisone in 7 of 33 courses and followed treatment with thyroid in 4 of 30 courses (P = 0.5, not significant [NS]). The mean pretreatment count in all patients was 12.3 million/ml. The mean post-treatment count with thyroid was 11.2 million/ml as compared with 13 million/ml for cortisone treatment (P = 0.4, NS). Pretreatment motility was 45% as compared with 44% following thyroid treatment and 43% following cortisone treatment (P = 0.7, NS). The pregnancy rate seemed to correlate with pretreatment counts rather than with the type of treatment. The efficacy of low-dose cortisone for idiopathic fertility would seem to be in question.
38名特发性不育男性被随机给予低剂量甲状腺素和低剂量可的松治疗。在33个疗程中，有7个疗程使用可的松治疗后怀孕；在30个疗程中，有4个疗程使用甲状腺素治疗后怀孕（P = 0.5，无显著性差异[NS]）。所有患者治疗前的平均精子计数为1230万/ml。使用甲状腺素治疗后的平均精子计数为1120万/ml，而使用可的松治疗后的平均精子计数为1300万/ml（P = 0.4，无显著性差异）。治疗前的精子活力为45%，使用甲状腺素治疗后为44%，使用可的松治疗后为43%（P = 0.7，无显著性差异）。怀孕率似乎与治疗前的精子计数相关，而非与治疗类型相关。低剂量可的松对特发性不育的疗效似乎存在疑问。
