Singer W D, Rabe E F, Haller J S
J Pediatr. 1980 Mar;96(3 Pt 1):485-9. doi: 10.1016/s0022-3476(80)80706-2.
Fifty-five infants with infantile spasms and hypsarrhythmia, who were treated with ACTH using 80 units im every other day for a mean period of ten months, were studied retrospectively and showed better results than infants using so-called nonsteroidal anticonvulsants or ACTH and steroids in other doses and with other time intervals. The study showed that the treatment with ACTH within the first month of onset of spasms produced a higher incidence of spasm-free state while on treatment, a shorter duration of spasms while on treatment, and a higher incidence of spasm-free state while on treatment, a shorter duration of spasms while on treatment, and a higher incidence of a spasm-free state when off treatment, compared to a similar regimen of ACTH begun after seizures had persusted for more than a month. The value of early treatment of infantile spasms suggests that the treatment of this disease should be regarded as a medical emergency.
对55例患有婴儿痉挛症和高峰失律的婴儿进行了回顾性研究，这些婴儿接受促肾上腺皮质激素（ACTH）治疗，每隔一天肌肉注射80单位，平均治疗期为10个月，结果显示比使用所谓非甾体类抗惊厥药或使用其他剂量及不同时间间隔的ACTH和类固醇的婴儿效果更好。研究表明，与在癫痫发作持续超过一个月后开始的类似ACTH治疗方案相比，在痉挛发作的第一个月内使用ACTH治疗，在治疗期间无痉挛状态的发生率更高，痉挛持续时间更短，且在停止治疗后无痉挛状态的发生率更高。婴儿痉挛症早期治疗的价值表明，这种疾病的治疗应被视为医疗急症。
