Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, SA, Italy.
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
Curr Neuropharmacol. 2023;21(8):1646-1665. doi: 10.2174/1570159X20666220706102708.
Managing epilepsy in people with an intellectual disability remains a therapeutic challenge and must take into account additional issues such as diagnostic difficulties and frequent drug resistance. Advances in genomic technologies improved our understanding of epilepsy and raised the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved in the development of the disease. In addition to conventional antiseizure medications (ASMs), ketogenic diet, hormone therapy and epilepsy surgery play an important role, especially in cases of drugresistance. This review aims to provide a comprehensive overview of the mainfactors influencing cognition in children and adolescents with epilepsy and the main therapeutic options available for the epilepsies associated with intellectual disability.
管理智障人士的癫痫仍然是一个治疗挑战，必须考虑到其他问题，如诊断困难和频繁的耐药性。基因组技术的进步提高了我们对癫痫的认识，并提出了开发针对疾病发展中涉及的关键分子机制的个体化治疗的可能性。除了传统的抗癫痫药物（ASMs）外，生酮饮食、激素治疗和癫痫手术也起着重要作用，尤其是在耐药性病例中。这篇综述旨在全面概述影响癫痫儿童和青少年认知的主要因素，以及与智力障碍相关的癫痫的主要治疗选择。
