抗生素治疗肠致病性大肠杆菌引起的肠胃炎

Antibiotics in the treatment of gastroenteritis caused by enteropathogenic Escherichia coli.

作者信息

Thorén A, Wolde-Mariam T, Stintzing G, Wadström T, Habte D

出版信息

J Infect Dis. 1980 Jan;141(1):27-31. doi: 10.1093/infdis/141.1.27.

DOI:10.1093/infdis/141.1.27

Abstract

The role of antibiotics in treating endemic infantile diarrhea caused by enteropathogenic Escherichia coli has not been determined. In a controlled study of 49 patients, one group received mecillinam and another group received trimethoprim-sulfamethoxazole. A third group served as control subjects. Serotype O111:B4 dominated. Treatment, as evaluated clinically on the third day, resulted in cure for 79% of those receiving mecillinam, 73% of those receiving trimethoprim-sulfamethoxazole, and 7% of the control subjects. Bacteriologic cure was confirmed in 53%, 53%, and 0, respectively. The statistically significant difference between antibiotic-treated patients and control subjects (P less than 0.001) indicated that antibiotics are an important supplement in the treatment of endemic severe diarrhea caused by enteropathogenic E. coli.

摘要

抗生素在治疗由致病性大肠杆菌引起的地方性婴儿腹泻中的作用尚未确定。在一项针对49名患者的对照研究中，一组接受美西林治疗，另一组接受甲氧苄啶-磺胺甲恶唑治疗。第三组作为对照对象。O111:B4血清型占主导。在第三天进行临床评估时，接受美西林治疗的患者中有79%治愈，接受甲氧苄啶-磺胺甲恶唑治疗的患者中有73%治愈，而对照对象中只有7%治愈。细菌学治愈分别在53%、53%和0的患者中得到证实。抗生素治疗患者与对照对象之间具有统计学意义的差异（P小于0.001），这表明抗生素是治疗由致病性大肠杆菌引起的地方性严重腹泻的重要补充。