糖尿病、肝硬化和胃癌患者血清α-L-岩藻糖苷酶和β-N-乙酰氨基葡萄糖苷酶活性升高。

Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.

作者信息

Reglero A, Carretero M I, Cabezas J A

出版信息

Clin Chim Acta. 1980 Apr 25;103(2):155-8. doi: 10.1016/0009-8981(80)90207-7.

Abstract

The activities of several glycosidases (alpha-L-fucosidase, alpha-D-mannosidase, alpha-D-galactosidase, beta-D-galactosidase, beta-N-acetylglucosaminidase and beta-D-glucuronidase) were determined in human sera from 10 normal subjects and in three groups each of 10 patients with diabetes mellitus, hepatic cirrhosis and gastric carcinoma. The results show significantly higher activities in the patients for alpha-L-fucosidase (p less than 0.001) and for beta-N-acetylglucosaminidase (p less than 0.1, p less than 0.001 and p less than 0.05, respectively), and smaller or not significantly greater values for the other glycosidases.

摘要

在10名正常受试者的人血清中以及分别在10例糖尿病、肝硬化和胃癌患者的三组人群中，测定了几种糖苷酶（α-L-岩藻糖苷酶、α-D-甘露糖苷酶、α-D-半乳糖苷酶、β-D-半乳糖苷酶、β-N-乙酰氨基葡萄糖苷酶和β-D-葡萄糖醛酸酶）的活性。结果显示，α-L-岩藻糖苷酶（p<0.001）和β-N-乙酰氨基葡萄糖苷酶（分别为p<0.1、p<0.001和p<0.05）在患者中的活性显著更高，而其他糖苷酶的值较小或无显著升高。