Shimizu M, Smith D F
Int Pharmacopsychiatry. 1978;13(1):34-8. doi: 10.1159/000468319.
Samples of saliva were collected from healthy subjects given a test dose of lithium carbonate. Lithium clearance in saliva was well related to salivary potassium clearance but not to salivary sodium clearance. Stimulation of adrenocortical activity by changing from the recumbent to the upright posture caused salivary sodium clearance to fall, but failed to affect the clearance of lithium and potassium in saliva. The findings show that the secretion of lithium in saliva resembles potassium secretion more than sodium secretion.
从接受碳酸锂测试剂量的健康受试者中采集唾液样本。唾液中锂的清除率与唾液中钾的清除率密切相关，但与唾液中钠的清除率无关。从卧位变为直立姿势刺激肾上腺皮质活动会导致唾液中钠的清除率下降，但未能影响唾液中锂和钾的清除率。研究结果表明，唾液中锂的分泌更类似于钾的分泌而非钠的分泌。
