Ben-Aryeh H, Naon H, Horovitz G, Szargel R, Gutman D
J Psychiatr Res. 1984;18(3):299-306. doi: 10.1016/0022-3956(84)90020-7.
Salivary and lacrimal secretion rates and salivary composition were examined in 22 manic-depressive patients on lithium therapy and in 21 matched, healthy controls. Serum immunoglobulins (IgG and IgA) were measured in these patients. Their oral health was examined and found to be unimpaired. Significantly lowered tear secretion was detected in the patients, while their salivary secretion rates were normal. The salivary concentrations of NA, K and IgA were significantly elevated in whole saliva. In parotid saliva, the concentrations of K and IgA were elevated, while Na was in the normal range. A significant correlation between serum and salivary lithium concentrations was found, indicating the usefulness of salivary measurements for monitoring. Informed consent of the patients was obtained after the nature of the procedures had been fully explained.
对22名接受锂盐治疗的躁郁症患者和21名相匹配的健康对照者的唾液和泪液分泌速率以及唾液成分进行了检测。对这些患者测定了血清免疫球蛋白（IgG和IgA）。检查发现他们的口腔健康未受损。检测到患者的泪液分泌显著降低，而他们的唾液分泌速率正常。全唾液中钠、钾和IgA的唾液浓度显著升高。腮腺唾液中钾和IgA的浓度升高，而钠在正常范围内。发现血清和唾液锂浓度之间存在显著相关性，表明唾液测量对于监测的有用性。在充分解释了操作性质后，获得了患者的知情同意。
