Pintor C, Facchinetti F, Puggioni R, Faedda A, Massafra C, Corda R, Genazzani A R
J Endocrinol Invest. 1980 Jan-Mar;3(1):25-8. doi: 10.1007/BF03348213.
In 40 girls aged from 2 to 14 years, subdivided into groups according to age and pubertal development, and in 6 adult female volunteers, plasma cortisol (F), pregnenolone (delta 5), dehydroepiandrosterone (DHA) progesterone (P), 17-hydroxyprogesterone (17P), androstenedione (A), testosterone (T) and estradiol (E2) were measured before and after short dexamethasone (DXM) suppression. The results confirmed the capacity of DXM to inhibit plasma steroids in all age groups, except T in 2-9 year old and P1 Tanner's stage girls. The percentage suppression of each given steroid was constant over the age groups from 6-9 years to P4-5 Tanner's stage, while lower suppression was found in 17P, P and DHA in 2-5 year old girls and in 17P, DHA and E2 in adult women. These results emphasize the fundamental role of ACTH as the overall stimulating factor of adrenal steroidogenesis but do not negate the possibility of another factor responsible for the development of the adrenal androgen secreting cells throughout prepuberty and puberty.
在40名年龄在2至14岁之间、根据年龄和青春期发育进行分组的女孩以及6名成年女性志愿者中，在短程地塞米松（DXM）抑制前后测量了血浆皮质醇（F）、孕烯醇酮（δ5）、脱氢表雄酮（DHA）、孕酮（P）、17-羟孕酮（17P）、雄烯二酮（A）、睾酮（T）和雌二醇（E2）。结果证实，除了2至9岁女孩和坦纳1期的P外，DXM能够抑制所有年龄组的血浆类固醇。从6至9岁到坦纳4至5期，每个特定类固醇的抑制百分比在各年龄组中是恒定的，而在2至5岁女孩的17P、P和DHA以及成年女性的17P、DHA和E2中发现抑制较低。这些结果强调了促肾上腺皮质激素作为肾上腺类固醇生成的总体刺激因子的基本作用，但并不排除在整个青春期前和青春期期间存在另一个负责肾上腺雄激素分泌细胞发育的因子的可能性。
