Genazzani A R, Pintor C, Corda R
J Clin Endocrinol Metab. 1978 Nov;47(5):974-9. doi: 10.1210/jcem-47-5-974.
Plasma levels of gonadotropins, PRL, T4, and adrenal and gonadal steroids were measured in two groups of 7- to 9-yr-old and 10- to 11-yr-old obese prepubertal girls, and were compared to those found in groups of nonobese girls of the same age. The data found in normal weight subjects confirm the data reported in the literature, showing a significant rise between the 7- to 9- and 10- to 11-yr groups, of FSH, pregnenolone, dehydroepiandrosterone, testosterone, and estradiol plasma levels, while LH, PRL, T4, cortisol, progesterone, 17-hydroxyprogesterone (17P), and androstenedione remained constant. In the obese subjects, pregnenolone and dehydroepiandrosterone levels are notably higher than in the normal girls, in the same range as those found in adult women; furthermore, they show no rise between the two age groups. The obese prepubertal groups had significantly higher progesterone, androstenedione, and PRL levels in comparison with those observed in girls of normal weight, but 17-hydroxyprogesterone, cortisol, testosterone, LH, and T4 were similar in both groups. Estradiol levels were markedly depressed in the obese girls; FSH levels were higher in the younger girls than in normal subjects. These data indicate that in prepubertal obesity, maturation of adrenal gland function (chiefly the delta 5 pathway), is notably enhanced, whereas gonadal secretion of estradiol is impaired in the presence of high levels of FSH and PRL.
对两组7至9岁以及10至11岁的肥胖青春期前女孩测定了促性腺激素、催乳素、甲状腺素（T4）以及肾上腺和性腺类固醇的血浆水平，并与同龄非肥胖女孩组的测定结果进行了比较。正常体重受试者的数据证实了文献报道的数据，显示在7至9岁组和10至11岁组之间，促卵泡激素（FSH）、孕烯醇酮、脱氢表雄酮、睾酮和雌二醇的血浆水平显著升高，而促黄体生成素（LH）、催乳素、T4、皮质醇、孕酮、17-羟孕酮（17P）和雄烯二酮保持不变。在肥胖受试者中，孕烯醇酮和脱氢表雄酮水平明显高于正常女孩，与成年女性的水平相当；此外，在两个年龄组之间它们没有升高。肥胖青春期前组的孕酮、雄烯二酮和催乳素水平显著高于正常体重女孩，但两组的17-羟孕酮、皮质醇、睾酮、LH和T4相似。肥胖女孩的雌二醇水平明显降低；较年轻女孩的FSH水平高于正常受试者。这些数据表明，青春期前肥胖时，肾上腺功能（主要是Δ5途径）的成熟显著增强，而在FSH和催乳素水平较高的情况下，性腺雌二醇的分泌受损。
