鼻咽癌患者中，针对爱泼斯坦-巴尔病毒特异性脱氧核糖核酸酶的抗体频率和水平升高。
Frequency and levels of antibodies to Epstein-Barr virus-specific DNase are elevated in patients with nasopharyngeal carcinoma.
作者信息
Cheng Y C, Chen J Y, Glaser R, Henle W
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6162-5. doi: 10.1073/pnas.77.10.6162.
Abstract
Sera from healthy individuals and patients with infectious mononucleosis, Burkitt lymphoma, nasopharyngeal carcinoma, or other malignancies were examined for their capacity to neutralize Epstein-Barr virus (EBV)-induced DNase activity. Sera were found that neutralized the EBV DNase but not herpes simplex virus type 1 or type 2 DNases, and vice versa. Sera from 46 of the 49 patients with nasopharyngeal carcinoma examined (94%) neutralized > 6 units of EBV DNase per ml of serum. In contrast, only 19% of 47 patients with Burkitt lymphoma, 12% of 183 patient with other malignancies, 4% of 58 patients with infectious mononucleosis, and none of 101 healthy individuals had such levels of neutralizing activity. The neutralizing factor was found in the IgG fraction derived from nasopharyngeal carcinoma sera. There was no correlation between the concentration of these antibodie and the titers of IgG ad IgA antibodies to the EBV capsid antigen, the early antigen complex, or the EBV-associated nuclear antigen.
摘要
检测了健康个体以及患有传染性单核细胞增多症、伯基特淋巴瘤、鼻咽癌或其他恶性肿瘤患者的血清中和爱泼斯坦-巴尔病毒（EBV）诱导的DNA酶活性的能力。发现血清能中和EBV DNA酶，但不能中和1型或2型单纯疱疹病毒DNA酶，反之亦然。在检测的49例鼻咽癌患者中，有46例（94%）的血清每毫升能中和超过6单位的EBV DNA酶。相比之下，47例伯基特淋巴瘤患者中只有19%、183例其他恶性肿瘤患者中只有12%、58例传染性单核细胞增多症患者中只有4%以及101名健康个体中无人具有如此水平的中和活性。中和因子存在于源自鼻咽癌血清的IgG组分中。这些抗体的浓度与针对EBV衣壳抗原、早期抗原复合物或EBV相关核抗原的IgG和IgA抗体滴度之间没有相关性。
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