Jelinek W R, Toomey T P, Leinwand L, Duncan C H, Biro P A, Choudary P V, Weissman S M, Rubin C M, Houck C M, Deininger P L, Schmid C W
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402. doi: 10.1073/pnas.77.3.1398.
DNA base sequence comparisons demonstrate that the principal family of 300-nucleotide interspersed human DNA sequences, the repetitive double-strand regions of HeLa cell heterogeneous nuclear RNA, and specific RNA polymerase III in vitro transcripts of cloned human DNA sequences are all representatives of a closely related family of sequences. A segment of approximately 30 residues of these sequences is highly conserved in mammalian evolution because it is also present in the interspersed repeated DNA sequences of Chinese hamsters. Further DNA sequence comparisons demonstrate that a portion of this highly conserved segment of repetitive mamalian DNA sequence is similar to a sequence found within a low molecular weight RNA that hydrogen-bonds to poly(A)-terminated RNA molecules of Chinese hamsters and a sequence that forms half of a perfect inverted repeat near the origin of DNA replication in papovaviruses.
DNA碱基序列比较表明，300个核苷酸散布的人类DNA序列的主要家族、HeLa细胞异质核RNA的重复双链区域以及克隆的人类DNA序列的特定RNA聚合酶III体外转录本都是一个密切相关的序列家族的代表。这些序列中大约30个残基的片段在哺乳动物进化中高度保守，因为它也存在于中国仓鼠的散布重复DNA序列中。进一步的DNA序列比较表明，这种重复的哺乳动物DNA序列的高度保守片段的一部分类似于在低分子量RNA中发现的一个序列，该序列与中国仓鼠的聚（A）末端RNA分子形成氢键，并且类似于在乳头瘤病毒DNA复制起点附近形成完美反向重复一半的序列。
