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分散重复序列的Alu家族。

The Alu family of dispersed repetitive sequences.

作者信息

Schmid C W, Jelinek W R

出版信息

Science. 1982 Jun 4;216(4550):1065-70. doi: 10.1126/science.6281889.

Abstract

A family of related sequences that includes approximately 500,000 members is the most prominent short dispersed repeat family in primate and rodent DNA's. The primate sequence is approximately 300 base pairs in length and is composed of two imperfectly repeated monomer units, whereas the rodent repeat consists of only a single monomer. Properties of this repeat sequence, its flanking sequences in chromosomal DNA, and RNA's transcribed from it suggest that it may be a mobile DNA element inserted at hundreds of thousands of different chromosomal locations.

摘要

一个包含约50万个成员的相关序列家族是灵长类和啮齿类动物DNA中最显著的短分散重复序列家族。灵长类序列长度约为300个碱基对,由两个不完全重复的单体单元组成,而啮齿类重复序列仅由一个单体组成。该重复序列的特性、其在染色体DNA中的侧翼序列以及从中转录的RNA表明,它可能是一个插入到数十万个不同染色体位置的可移动DNA元件。

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