大脑中的胆囊收缩素受体：特性与分布
Cholecystokinin receptors in the brain: characterization and distribution.
作者信息
Saito A, Sankaran H, Goldfine I D, Williams J A
出版信息
Science. 1980 Jun 6;208(4448):1155-6. doi: 10.1126/science.6246582.
PMID:6246582
Abstract
Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.
摘要
用具有完全生物活性的胆囊收缩素类似物——碘125标记的博尔顿-亨特胆囊收缩素，测定大鼠脑微粒部分中特定的胆囊收缩素结合位点。在已知含有免疫反应性胆囊收缩素的脑区检测到结合。结合是可饱和的、可逆的，具有高亲和力（解离常数为1.7×10⁻⁹ M），并且被胆囊收缩素类似物抑制，但不被无关激素抑制。
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