McCracken J A
Adv Prostaglandin Thromboxane Res. 1980;8:1329-44.
The interaction of the ovarian steroid hormones (estrogen and progesterone) and the polypeptide hormone of posterior pituitary origin (oxytocin) appear to regulate the ovine estrous cycle by controlling production of the uterine luteolytic hormone PGF2 alpha. From our results, it appears that these steroid hormones may control PGF2 alpha release by regulating the availability of receptors for oxytocin in the endometrium, the primary site of PGF2 alpha production. Secondarily the ovarian steroid hormones may also regulate basal endogenous levels of oxytocin in the blood stream which may reinforce the luteolytic release of PGF2 alpha. Similar mechanisms may also be operative during the initiation of parturition in which steroid hormones, OT, and PGF2 alpha appear to play major roles (26). In addition to the known interdependence of steroid hormones and the gonadotropins (FSH, LH, and prolactin) required to initiate follicular growth, ovulation, and CL function, there appears to be a second interdependence required to terminate the ovarian cycle via the uterine luteolytic hormone PGF2 alpha, namely by the interaction between ovarian steroids and the posterior pituitary hormone, OT. Thus for both the initiation and termination of the ovarian cycle, there is evidence of a close interaction between the ovary and brain.
卵巢甾体激素（雌激素和孕酮）与源自垂体后叶的多肽激素（催产素）之间的相互作用，似乎通过控制子宫溶黄体激素PGF2α的产生来调节绵羊的发情周期。从我们的结果来看，这些甾体激素似乎可能通过调节子宫内膜（PGF2α产生的主要部位）中催产素受体的可用性来控制PGF2α的释放。其次，卵巢甾体激素也可能调节血流中催产素的基础内源性水平，这可能会加强PGF2α的溶黄体释放。类似的机制在分娩启动过程中可能也起作用，其中甾体激素、OT和PGF2α似乎发挥主要作用（26）。除了启动卵泡生长、排卵和黄体功能所需的甾体激素与促性腺激素（FSH、LH和催乳素）之间已知的相互依赖性外，似乎还存在另一种相互依赖性，即通过子宫溶黄体激素PGF2α来终止卵巢周期，也就是通过卵巢甾体激素与垂体后叶激素OT之间的相互作用。因此，对于卵巢周期的启动和终止，都有证据表明卵巢与脑之间存在密切的相互作用。
