• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肾上腺皮质的毛细血管具有氨肽酶A和血管紧张素转换酶活性。

Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities.

作者信息

Del Vecchio P J, Ryan J W, Chung A, Ryan U S

出版信息

Biochem J. 1980 Feb 15;186(2):605-8. doi: 10.1042/bj1860605.

DOI:10.1042/bj1860605
PMID:6246891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161614/
Abstract

The enzymes required to convert the prohormone angiotensin I into angiotensins II and III, secretagogues of aldosterone, are enriched in association with capillary endothelium isolated from rat adrenal cortex. Thus the secretion of aldosterone may be controlled, in part, by processing of peptides occurring within the adrenal gland itself.

摘要

将前体激素血管紧张素I转化为血管紧张素II和III（醛固酮的促分泌素）所需的酶，在从大鼠肾上腺皮质分离出的毛细血管内皮中大量存在。因此，醛固酮的分泌可能部分受肾上腺自身内肽加工过程的控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ef/1161614/d6318508307e/biochemj00428-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ef/1161614/d6318508307e/biochemj00428-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ef/1161614/d6318508307e/biochemj00428-0218-a.jpg

相似文献

1
Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities.肾上腺皮质的毛细血管具有氨肽酶A和血管紧张素转换酶活性。
Biochem J. 1980 Feb 15;186(2):605-8. doi: 10.1042/bj1860605.
2
Cellular and subcellular immunohistochemical localization of angiotensin-converting enzyme in the rat adrenal gland.
Lab Invest. 1987 Apr;56(4):364-71.
3
Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries.血管紧张素II向血管紧张素III的强制性代谢对于牛肾上腺皮质动脉的球状带细胞介导的舒张作用。
Endocrinology. 2018 Jan 1;159(1):238-247. doi: 10.1210/en.2017-00759.
4
Proteolytic enzymes in human leukemic lymphoid cells. III. Aminopeptidases, angiotensin-converting enzyme, and its inhibitor in cells of different immunological phenotype.人类白血病淋巴样细胞中的蛋白水解酶。III. 不同免疫表型细胞中的氨肽酶、血管紧张素转换酶及其抑制剂
Biochemistry (Mosc). 1999 Apr;64(4):448-55.
5
Angiotensin-converting enzyme: vascular endothelial localization.
Science. 1976 Mar 12;191(4231):1050-1. doi: 10.1126/science.175444.
6
Peptidyl dipeptidase in rabbit brain microvessels.兔脑微血管中的肽基二肽酶
Biochim Biophys Acta. 1978 Oct 12;526(2):537-46. doi: 10.1016/0005-2744(78)90144-4.
7
Hormonal regulation of capillary fenestrae in the rat adrenal cortex: quantitative studies using objective lens staging scanning electron microscopy.
Scan Electron Microsc. 1986(Pt 4):1381-93.
8
[Ultrastructure of the pericappillary space of the adrenal cortex of rats exposed to low temperatures].[低温暴露大鼠肾上腺皮质毛细血管周间隙的超微结构]
Boll Soc Ital Biol Sper. 1974 Mar 15;50(5):250-2.
9
Endothelial angiotensin-converting enzyme and neutral endopeptidase in isolated human umbilical vein: an effective bradykinin inactivation pathway.内皮素血管紧张素转换酶和中性内肽酶在人脐静脉中的作用：一种有效的缓激肽失活途径。
Eur J Pharmacol. 2011 Sep 30;667(1-3):271-7. doi: 10.1016/j.ejphar.2011.05.045. Epub 2011 Jun 1.
10
Dexamethasone selectively regulates the activity of enzymatic markers of cerebral endothelial cell lines.地塞米松选择性调节脑内皮细胞系酶标志物的活性。
In Vitro Cell Dev Biol. 1992 Jul-Aug;28A(7-8):537-43. doi: 10.1007/BF02634138.

引用本文的文献

1
Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity.
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1222-6. doi: 10.1073/pnas.90.4.1222.
2
Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.凝血酶受体肽通过受体脱敏抑制凝血酶诱导的内皮通透性增加。
J Cell Biol. 1993 Mar;120(6):1491-9. doi: 10.1083/jcb.120.6.1491.
3
Cytochemical demonstration of an enzymatic production of hydrogen peroxide on the surface of isolated thyroid capillaries.
Cell Tissue Res. 1983;228(2):337-44. doi: 10.1007/BF00204883.
4

本文引用的文献

1
A mammalian peptidase specific for the hydrolysis of N-terminal alpha-L-glutamyl and aspartyl residues.一种特异性水解N端α-L-谷氨酰基和天冬氨酰基残基的哺乳动物肽酶。
Nature. 1962 Jun 2;194:867. doi: 10.1038/194867a0.
2
Concentrations of angiotensin-converting enzyme in tissues of the rat.大鼠组织中血管紧张素转换酶的浓度。
Biochim Biophys Acta. 1971 Oct;250(1):261-5. doi: 10.1016/0005-2744(71)90142-2.
3
Properties of renin substrate in rabbit plasma with a note on its assay.兔血浆中肾素底物的特性及其测定方法的说明
Monoclonal antibody against angiotensin-converting enzyme: its use as a marker for murine, bovine, and human endothelial cells.抗血管紧张素转换酶单克隆抗体：其作为小鼠、牛和人内皮细胞标志物的用途。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7891-5. doi: 10.1073/pnas.79.24.7891.
5
Capillary endothelial cell cultures: phenotypic modulation by matrix components.毛细血管内皮细胞培养：基质成分对表型的调节作用
J Cell Biol. 1983 Jul;97(1):153-65. doi: 10.1083/jcb.97.1.153.
6
Dipeptidyl peptidase IV in mammalian lungs.
Lung. 1985;163(1):33-54. doi: 10.1007/BF02713804.
7
Aminopeptidase A activity of the murine B-lymphocyte differentiation antigen BP-1/6C3.小鼠B淋巴细胞分化抗原BP-1/6C3的氨肽酶A活性
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):676-80. doi: 10.1073/pnas.88.2.676.
8
Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.肿瘤坏死因子-α介导的谷胱甘肽减少增加了肺血管内皮细胞对过氧化氢的敏感性。
J Clin Invest. 1992 Mar;89(3):794-802. doi: 10.1172/JCI115658.
Biochem J. 1968 Jul;108(4):687-92. doi: 10.1042/bj1080687.
4
A rapid simple method for the assay of renin in rabbit plasma.一种快速简便的兔血浆肾素测定方法。
Biochem J. 1968 Jul;108(4):679-85. doi: 10.1042/bj1080679.
5
Serum aminopeptidases, "angiotensinase," and hypertension. II. Amino acid beta-napthylamide hydrolysis by normal and hypertensive serum.血清氨基肽酶、“血管紧张素酶”与高血压。II. 正常血清和高血压血清对氨基酸β-萘酰胺的水解作用
Biochem Pharmacol. 1965 May;14(5):853-61. doi: 10.1016/0006-2952(65)90105-x.
6
Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.
Circ Res. 1975 Jun;36(6 Suppl 1):38-48. doi: 10.1161/01.res.36.6.38.
7
Des-Asp1-angiotensin I: a metabolite of angiotensin I in the perfused feline adrenal.去天冬氨酸1-血管紧张素I：灌注猫肾上腺中血管紧张素I的一种代谢产物。
Eur J Pharmacol. 1976 Jul;38(1):113-21. doi: 10.1016/0014-2999(76)90207-7.
8
Organ specificity of angiotensin II and Des-aspartyl angiotensin II in the conscious rat.清醒大鼠体内血管紧张素II和去天冬氨酰血管紧张素II的器官特异性
J Pharmacol Exp Ther. 1976 Aug;198(2):450-6.
9
[Des-Asp1] angiotensin II: mediator of the renin-angiotensin system?[去天冬氨酸1]血管紧张素II：肾素-血管紧张素系统的介质？
Fed Proc. 1977 Apr;36(5):1766-70.
10
Angiotensinase activity in red blood cell membranes and intact adrenal cells.
Res Commun Chem Pathol Pharmacol. 1977 Dec;18(4):697-707.