Cuthbert A W, Herrera F C, Schuz A D, Wilson S A
Br J Pharmacol. 1980 May;69(1):8-10. doi: 10.1111/j.1476-5381.1980.tb10875.x.
Vanadate increases the cyclic adenosine 3',5'-monophosphate (cyclic AMP) content of frog skin epithelium and apparently antagonizes the stimulation by isoprenaline. The effect appears to be a direct activation of adenyl cyclase. This new effect of vanadate together with the inhibitory effects on Na-K ATPase may explain the irregular effects on sodium transport.
钒酸盐可增加蛙皮上皮细胞中3',5'-环磷酸腺苷(环磷酸腺苷)的含量,并且明显拮抗异丙肾上腺素的刺激作用。这种作用似乎是对腺苷酸环化酶的直接激活。钒酸盐的这种新作用连同其对钠钾ATP酶的抑制作用,可能解释了其对钠转运的不规则作用。