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大鼠肝脏中两种α-肾上腺素能结合位点的亚分类

Subclassification of two types of alpha-adrenergic binding sites in rat liver.

作者信息

El-Refai M F, Exton J H

出版信息

Eur J Pharmacol. 1980 Mar 21;62(2-3):201-4. doi: 10.1016/0014-2999(80)90276-9.

DOI:10.1016/0014-2999(80)90276-9
PMID:6247157
Abstract

Drug specificity studies with prazosin and yohimbine indicated that the two types of alpha-adrenergic binding sites identified using [3H]-epinephrine and [3H]-dihydroergocryptine in rat liver plasma membranes both belong to the alpha 1-sublcass.

摘要

使用哌唑嗪和育亨宾进行的药物特异性研究表明，在大鼠肝细胞膜中使用[3H]-肾上腺素和[3H]-二氢麦角隐亭鉴定出的两种α-肾上腺素能结合位点均属于α1亚类。

相似文献

1
Subclassification of two types of alpha-adrenergic binding sites in rat liver.大鼠肝脏中两种α-肾上腺素能结合位点的亚分类
Eur J Pharmacol. 1980 Mar 21;62(2-3):201-4. doi: 10.1016/0014-2999(80)90276-9.
2
[3H]Dihydroergocryptine binding to alpha-adrenergic receptors of human platelets. A reassessment using the selective radioligands [3H]prazosin, [3H]yohimbine, and [3H]rauwolscine.[3H]二氢麦角隐亭与人血小板α-肾上腺素能受体的结合。使用选择性放射性配体[3H]哌唑嗪、[3H]育亨宾和[3H]萝芙木碱的重新评估。
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3
Binding of [3H]-prazosin and [3H]-dihydroergocryptine to rat cardiac alpha-adrenoceptors.[3H] -哌唑嗪和[3H] -二氢麦角隐亭与大鼠心脏α-肾上腺素能受体的结合
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4
Evidence for two alpha-adrenergic binding sites in liver plasma membranes. Studies with [3H]epinephrine and [3H]dihydroergocryptine.肝细胞膜中两个α-肾上腺素能结合位点的证据。用[3H]肾上腺素和[3H]二氢麦角隐亭进行的研究。
J Biol Chem. 1979 Jun 10;254(11):4375-86.
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Arch Int Pharmacodyn Ther. 1980 Aug;246(2):237-50.
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Effects of trypsin on binding of [3H]epinephrine and [3H]-dihydroergocryptine to rat liver plasma membranes. Evidence for interconversion of binding sites.
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Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na.大鼠肾皮质中α-肾上腺素能受体亚型的特性。鸟苷酸和钠对α1-和α2-肾上腺素能受体的差异调节。
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Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands.肝细胞膜中的α-肾上腺素能受体：用亚型选择性放射性配体进行描述。
Life Sci. 1981 Jan 19;28(3):265-72. doi: 10.1016/0024-3205(81)90732-3.
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Two distinct alpha1-adrenergic receptor sites in rat liver: differential binding of (--)-[3H]dihydroergocryptine. Effects of guanine nucleotides and proteolysis; implications for a two-site model of alpha-receptor regulation.大鼠肝脏中两种不同的α1-肾上腺素能受体位点：（--）-[3H]二氢麦角隐亭的差异结合。鸟嘌呤核苷酸和蛋白水解的影响；对α受体调节双位点模型的意义。
Biochem Pharmacol. 1981 Jun 15;30(12):1665-75. doi: 10.1016/0006-2952(81)90395-6.

引用本文的文献

1
Alpha 1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats.在磷酸化酶b激酶缺陷的gsd/gsd大鼠的肝细胞中，α1-肾上腺素能刺激Ca2+动员而不激活磷酸化酶。
Biochem J. 1981 Aug 15;198(2):379-83. doi: 10.1042/bj1980379.
2
Binding and uptake of [3H]adrenaline by perfused rat liver.灌注大鼠肝脏对[3H]肾上腺素的结合与摄取
Biochem J. 1984 Mar 15;218(3):765-73. doi: 10.1042/bj2180765.
3
Adrenergic regulation of glycogenolysis in rat liver after cholestasis. Modulation of the balance between alpha 1 and beta 2 receptors.
胆汁淤积后大鼠肝脏糖原分解的肾上腺素能调节。α1和β2受体之间平衡的调节。
J Clin Invest. 1983 Mar;71(3):476-86. doi: 10.1172/jci110792.
4
Effects of adrenalectomy on binding to and actions of adrenergic receptors.肾上腺切除术对肾上腺素能受体结合及作用的影响。
Biochem J. 1986 Jul 15;237(2):527-31. doi: 10.1042/bj2370527.
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Alpha-adrenergic receptor regulation of Ca2+/Mg2+-ATPase in brain synaptic membranes.脑突触膜中钙/镁 -ATP酶的α-肾上腺素能受体调节
Neurochem Res. 1987 Sep;12(9):801-7. doi: 10.1007/BF00971519.