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在磷酸化酶b激酶缺陷的gsd/gsd大鼠的肝细胞中，α1-肾上腺素能刺激Ca2+动员而不激活磷酸化酶。

Alpha 1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats.

作者信息

Blackmore P F, Exton J H

出版信息

Biochem J. 1981 Aug 15;198(2):379-83. doi: 10.1042/bj1980379.

DOI:10.1042/bj1980379
PMID:6948557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163259/
Abstract

Phenylephrine, vasopressin and the bivalent cation ionophore A23187 mobilized Ca2+ normally, but failed to activate phosphorylase, in hepatocytes from gsd/gsd rats with a deficiency of liver phosphorylase b kinase. These data provide strong evidence that phosphorylase b kinase is the site of action of the Ca2+ mobilized intracellularly during alpha 1-adrenergic activation of phosphorylase in liver cells.

摘要

去氧肾上腺素、血管加压素和二价阳离子载体A23187在来自缺乏肝磷酸化酶b激酶的gsd/gsd大鼠的肝细胞中能正常地动员Ca2+，但不能激活磷酸化酶。这些数据提供了强有力的证据，表明磷酸化酶b激酶是肝细胞中α1-肾上腺素能激活磷酸化酶过程中细胞内动员的Ca2+的作用位点。

相似文献

1
Alpha 1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats.在磷酸化酶b激酶缺陷的gsd/gsd大鼠的肝细胞中，α1-肾上腺素能刺激Ca2+动员而不激活磷酸化酶。
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引用本文的文献

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本文引用的文献

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Hormonal effects on calcium homeostasis in isolated hepatocytes.激素对分离肝细胞钙稳态的影响。
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Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.二酰基甘油对钙和磷脂依赖性蛋白激酶的激活作用及其与磷脂酰肌醇代谢的可能关系。
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Glycogen-storage disease in rats, a genetically determined deficiency of liver phosphorylase kinase.大鼠糖原贮积病，一种由基因决定的肝磷酸化酶激酶缺乏症。
Biochem J. 1980 Apr 15;188(1):99-106. doi: 10.1042/bj1880099.
4
Liver glycogen synthase in rats with a glycogen-storage disorder. The role of glycogen in the regulation of glycogen synthase.患有糖原贮积症大鼠的肝脏糖原合酶。糖原在糖原合酶调节中的作用。
Eur J Biochem. 1980;108(1):73-7. doi: 10.1111/j.1432-1033.1980.tb04697.x.
5
Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands.肝细胞膜中的α-肾上腺素能受体：用亚型选择性放射性配体进行描述。
Life Sci. 1981 Jan 19;28(3):265-72. doi: 10.1016/0024-3205(81)90732-3.
6
Calcium movements in in situ mitochondria following activation of alpha-adrenergic receptors in rat liver cells.大鼠肝细胞中α-肾上腺素能受体激活后原位线粒体中的钙运动。
FEBS Lett. 1980 Jun 30;115(2):243-6. doi: 10.1016/0014-5793(80)81178-1.
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Effects of trypsin on binding of [3H]epinephrine and [3H]-dihydroergocryptine to rat liver plasma membranes. Evidence for interconversion of binding sites.
J Biol Chem. 1980 Jun 25;255(12):5853-8.
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Subclassification of two types of alpha-adrenergic binding sites in rat liver.大鼠肝脏中两种α-肾上腺素能结合位点的亚分类
Eur J Pharmacol. 1980 Mar 21;62(2-3):201-4. doi: 10.1016/0014-2999(80)90276-9.
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Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.放射性配体与α-肾上腺素能受体结合的异质性。关于受体亚型的激动剂结合的鸟嘌呤核苷酸调节分析。
J Biol Chem. 1980 May 25;255(10):4645-52.
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Studies on the alpha-adrenergic activation of hepatic glucose output. alpha-Adrenergic activation of phosphorylase by immobilized epinephrine.
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