在磷酸化酶b激酶缺陷的gsd/gsd大鼠的肝细胞中，α1-肾上腺素能刺激Ca2+动员而不激活磷酸化酶。
Alpha 1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats.
作者信息
Blackmore P F, Exton J H
出版信息
Biochem J. 1981 Aug 15;198(2):379-83. doi: 10.1042/bj1980379.
Abstract
Phenylephrine, vasopressin and the bivalent cation ionophore A23187 mobilized Ca2+ normally, but failed to activate phosphorylase, in hepatocytes from gsd/gsd rats with a deficiency of liver phosphorylase b kinase. These data provide strong evidence that phosphorylase b kinase is the site of action of the Ca2+ mobilized intracellularly during alpha 1-adrenergic activation of phosphorylase in liver cells.
摘要
去氧肾上腺素、血管加压素和二价阳离子载体A23187在来自缺乏肝磷酸化酶b激酶的gsd/gsd大鼠的肝细胞中能正常地动员Ca2+，但不能激活磷酸化酶。这些数据提供了强有力的证据，表明磷酸化酶b激酶是肝细胞中α1-肾上腺素能激活磷酸化酶过程中细胞内动员的Ca2+的作用位点。
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