Neubauer R H, Rabin H, Dunn F E
Infect Immun. 1980 Feb;27(2):549-55. doi: 10.1128/iai.27.2.549-555.1980.
Herpesvirus saimiri is a horizontally transmitted virus of squirrel monkeys (Saimiri sciureus) which, when inoculated into owl monkeys (Aotus trivirgatus), induces fatal malignant lymphoma in 75 to 80% of the animals. Previous immunological and virological studies have not indicated why 20 to 25% of inoculated owl monkeys develop a chronic, disease-free H. saimiri infection. In the present study, we examined two parameters to explain why certain owl monkeys are resistant to H. saimiri-induced disease. The first possibility was that the animals in which H. saimiri established a chronic infection were all of the same karyotypic class. In studying four such animals, we found that three of the seven known karyotyes were represented, indicating that chromosome polymorphism does not explain disease resistance. The second possibility examined was that animals which develop disease do so as a result of a failure in specific anti-H. saimiri cell-mediated immunity. Naturally infected squirrel monkeys exhibited long-lasting, virus-specific cell-mediated immunity in a lymphocyte proliferation assay, whereas such reactivity could not be demonstrated either in chronically infected owl monkeys or in an owl monkey with a primary H. saimiri infection. The failure of owl monkeys to respond to viral antigens was not due to a basic immunological defect, since these animals gave normal responses to heterologous cells and were capable of being sensitized with the protein antigen keyhole limpet hemocyanin.
赛氏疱疹病毒是松鼠猴（松鼠猴属）的一种水平传播病毒，当接种到夜猴（三带夜猴）体内时，会在75%至80%的动物中诱发致命的恶性淋巴瘤。以往的免疫学和病毒学研究并未表明，为什么20%至25%接种病毒的夜猴会出现慢性的、无疾病的赛氏疱疹病毒感染。在本研究中，我们研究了两个参数，以解释为什么某些夜猴对赛氏疱疹病毒诱发的疾病具有抗性。第一种可能性是，赛氏疱疹病毒在其中建立慢性感染的动物都属于同一核型类别。在研究四只这样的动物时，我们发现，在已知的七种核型中，有三种核型出现了，这表明染色体多态性并不能解释抗病性。研究的第二种可能性是，患病动物发病是由于特异性抗赛氏疱疹病毒细胞介导免疫功能失败所致。在淋巴细胞增殖试验中，自然感染的松鼠猴表现出持久的、病毒特异性的细胞介导免疫，而在慢性感染的夜猴或初次感染赛氏疱疹病毒的夜猴中，均未表现出这种反应性。夜猴对病毒抗原无反应，并非由于基本的免疫缺陷，因为这些动物对异源细胞反应正常，并且能够被蛋白质抗原钥孔血蓝蛋白致敏。
