皮下注射2,6,10,14-四甲基十五烷对浆细胞瘤生长的影响。
Effect of subcutaneously administered 2,6,10,14-tetramethylpentadecane on plasmacytoma growth.
作者信息
Platica M, Bojko C, Steiner G, Hollander V P
出版信息
Cancer Res. 1980 Jul;40(7):2229-33.
PMID:6248200
Abstract
2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immunity, have been considered.
摘要
2,6,10,14-四甲基十五烷（姥鲛烷），与浆细胞瘤接种物同时皮下注射，可增强肿瘤细胞的移植能力。该效应具有剂量和时间依赖性。仅浆细胞瘤（MOPC-315和MPC-11）表现出这种增强作用，而所测试的小鼠淋巴肉瘤和软骨肉瘤则未表现出该作用。已经考虑了多种机制，如应激以及体液免疫和细胞免疫的抑制。
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