McLoughlin L, Lowry P J, Ratter S, Besser G M, Rees L H
Clin Endocrinol (Oxf). 1980 Mar;12(3):287-92. doi: 10.1111/j.1365-2265.1980.tb02712.x.
The aim of this study was to establish whether or not a peptide with chromatographic and immunological properties of beta-endorphin exists in human plasma. Using direct chromatography under conditions designed to minimize generation of beta-endorphin and beta-MSH from beta-LPH, we invariably found a peptide with beta-endorphin immunoreactivity eluting in the position of beta h-endorphin on gel chromatography in samples of plasma from patients with elevated ACTH and LPH levels. beta-MSH was only found in the plasma of one patient with the ectopic ACTH syndrome.
本研究的目的是确定人血浆中是否存在具有β-内啡肽色谱和免疫特性的肽。在旨在尽量减少β-LPH生成β-内啡肽和β-MSH的条件下进行直接色谱分析，我们始终在促肾上腺皮质激素（ACTH）和促脂解素（LPH）水平升高患者的血浆样本中发现一种具有β-内啡肽免疫反应性的肽，其在凝胶色谱上的洗脱位置与βh-内啡肽相同。仅在一名患有异位ACTH综合征的患者血浆中发现了β-MSH。
