重水对人体皮肤反应性及血液白细胞组胺释放的增强作用
Potentiation of cutaneous reactivity and blood leucocyte histamine release by deuterium oxide in human beings.
作者信息
Vervloet D, Vellieux P, Charpin J
出版信息
Acta Allergol. 1976 Oct;31(5):367-72. doi: 10.1111/j.1398-9995.1976.tb01696.x.
Abstract
Deuterium oxide (D2O) is known to potentiate non-cytotoxic histamine release in vitro. It has been shown (5) that D2O could also potentiate in vivo immediate-type hypersensitivity in dogs and monkeys. Present studies demonstrate potentiation in vivo by D2O of the cutaneous reactivity in 48/80, PHA and Dermatophagoides cutaneous reactions in human beings. PHA histamine release from human leucocytes is also potentiated by D2O in vitro.
摘要
已知氧化氘（D2O）在体外可增强非细胞毒性组胺的释放。研究表明（5），D2O在体内也可增强犬和猴的速发型超敏反应。目前的研究证明，D2O在体内可增强人类对48/80、PHA和粉尘螨的皮肤反应性。D2O在体外也可增强人白细胞释放PHA组胺。
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