日本脑炎病毒的胎盘感染

Transplacental infection with Japanese encephalitis virus.

作者信息

Chaturvedi U C, Mathur A, Chandra A, Das S K, Tandon H O, Singh U K

出版信息

J Infect Dis. 1980 Jun;141(6):712-5. doi: 10.1093/infdis/141.6.712.

DOI:10.1093/infdis/141.6.712

Abstract

During a widespread epidemic of Japanese encephalitis, five pregnant women affected by the illness were observed. The diagnosis of Japanese encephalitis virus (JEV) infection was established on the basis of clinical presentation, rising titers of hemagglutination-inhibiting antibody, and the presence of specific IgM antibodies. Two women aborted, two were delivered of apparently normal children, and the fate of one case is not known. From brain, liver, and placental tissues of one of the aborted fetuses, JEV was isolated. This appears to be the first report of human transplacental infection with JEV.

摘要

在一次日本脑炎广泛流行期间，观察到5名患病孕妇。根据临床表现、血凝抑制抗体滴度升高以及特异性IgM抗体的存在，确诊为日本脑炎病毒（JEV）感染。两名妇女流产，两名顺利产下外观正常的婴儿，还有一例情况不明。从其中一名流产胎儿的脑、肝和胎盘组织中分离出了JEV。这似乎是关于JEV经胎盘感染人类的首例报告。