Miller A R
Mech Ageing Dev. 1980 Apr;12(4):393-7. doi: 10.1016/0047-6374(80)90071-8.
The electron spin resonance spectrum of a suicidal inositol auxotroph of Neurospora crassa, previously used as a model of cellular aging, exhibits a high-spin Fe(III) signal whose intensity increases as a function of the mutant's "senescence". Surprisingly, the intensity of the signal is further enhanced by the exogenous antioxidant nordihydroguaiaretic acid, which reportedly decreases the rate of senescence.
粗糙脉孢菌自杀性肌醇营养缺陷型的电子自旋共振谱,先前被用作细胞衰老模型,显示出一种高自旋Fe(III)信号,其强度随突变体的“衰老”而增加。令人惊讶的是,外源性抗氧化剂去甲二氢愈创木酸进一步增强了该信号的强度,据报道这种抗氧化剂会降低衰老速率。