Adám-Vizi V, Horváth I, Vizi E S
Pharmacology. 1980;20(5):268-74. doi: 10.1159/000137372.
The effect of primycin, an antibiotic known to inhibit potassium conductance, was studied on acetylcholine (ACh) release from the nerve terminals of the Auerbach plexus and cortical slice of the rat. Primycin enhanced the resting release of ACh; however, it failed to affect the amount of ACh released by a single shock. It has no effect on Na+K+-activated ATPase. Its effect on Ach release was prevented by tetrodotoxin and by Ca removal. It is concluded that its effect on potassium conductance might account for its ACh-releasing effect: it produces depolarization and spontaneous firing.
研究了已知能抑制钾离子电导的抗生素原霉素对大鼠奥尔巴赫神经丛神经末梢和皮质切片中乙酰胆碱（ACh）释放的影响。原霉素增强了ACh的静息释放；然而，它未能影响单次电击释放的ACh量。它对钠钾激活的ATP酶没有作用。河豚毒素和去除钙离子可阻止其对ACh释放的影响。得出的结论是，其对钾离子电导的影响可能是其释放ACh的原因：它产生去极化和自发放电。
