在血小板 - 内皮细胞混合物中，二高 - γ - 亚麻酸（20:3 ω6）比二十碳五烯酸（20:5 ω3）具有更强的抗聚集作用。
Dihomogammalinolenic acid (20:3 omega 6) is more anti-aggregatory than eicosapentaenoic (20:5 omega 3) in a platelet-endothelial cell mixture.
作者信息
Lagarde M, Burtin M, Dechavanne M, Sicard B, Coiffier B
出版信息
Prostaglandins Med. 1980 Mar;4(3):177-83. doi: 10.1016/0161-4630(80)90080-4.
PMID:6248913
Abstract
The effect of 20:3 omega 6, the precursor of 1 series prostaglandins was to inhibit platelet aggregation more strongly than either 20:5 omega 3, the precursor of 3 series prostaglandins or 20:3 omega 3 which is not a substrate of prostaglandin synthetase. When platelets and dissociated endothelial cells were pretreated with 20:3 omega 6, platelet aggregation in the presence of endothelial cells was much more inhibited than after 20:5 omega 3 pretreatment.
摘要
1系列前列腺素的前体20:3ω6对血小板聚集的抑制作用比3系列前列腺素的前体20:5ω3或不是前列腺素合成酶底物的20:3ω3更强。当血小板和解离的内皮细胞用20:3ω6预处理时，在内皮细胞存在的情况下血小板聚集比用20:5ω3预处理后受到的抑制要大得多。
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