Kolodie L, Phelipp X, Baccard C
Sem Hop. 1980;56(17-18):832-6.
FDP were studied in the synovial fluid of 23 patients with various rheumatological diseases. The levels, measured by the passive hemagglutination inhibition technique (Merskey technique), showed variable values, but were always found to be present. On half the cases a number of these molecules could be eliminated by a high dose of thrombin. Using three immune sera (anti-fibrinogen, anti-D, anti-E), immunoelectrophoresis revealed in half the cases one central nonmigrating arc and another with cathodic migration. This differs from results using FDP obtained by the digestion of fibrinogen by plasmin, but is, however, analagous with those obtained in vitro by the action of proteases of leukocyte origin. These results suggest that the intense fibrinogen catabolism within the pathological joints results from the action of proteolytic enzymes other than plasmin.
对23例患有各种风湿性疾病患者的滑液中的纤维蛋白降解产物（FDP）进行了研究。通过被动血凝抑制技术（默斯基技术）测量的水平显示出不同的值，但始终发现其存在。在一半的病例中，高剂量的凝血酶可消除许多这些分子。使用三种免疫血清（抗纤维蛋白原、抗-D、抗-E），免疫电泳在一半的病例中显示出一条中央不迁移弧和另一条向阴极迁移的弧。这与通过纤溶酶消化纤维蛋白原获得的FDP的结果不同，然而，与通过白细胞来源的蛋白酶在体外作用获得的结果相似。这些结果表明，病理性关节内强烈的纤维蛋白原分解代谢是由纤溶酶以外的蛋白水解酶的作用引起的。
