Hara M, Saito Y, Komatsu T, Kodama H, Abo W, Chiba S, Nakao T
Microbiol Immunol. 1981;25(9):905-13. doi: 10.1111/j.1348-0421.1981.tb00095.x.
A 3-year-old boy with agammaglobulinemia developed paralytic poliomyelitis on day 553 after being fed poliovaccine. Non-vaccine-like type 2 polioviruses were isolated from 22 stools obtained within 684 days after the onset of illness. Antigenic variations were observed among these viruses. The non-vaccine-like virus isolated 1 week after the onset of paralysis differed in virulence from the Sabin type 2 vaccine strain in the neurovirulence test in monkeys, and did not have the same antigenic character as the wild virulent strains. Another virus isolated on day 348 before the onset of illness was also classified as non-vaccine-like. However, the Sabin type 2 strain was shown to be homologous with this strain by the McBride test. Some Sabin-like particles were found in this stock virus. We may conclude that the non-vaccine-like virus isolates were derived from Sabin vaccine by antigenic variation that occurred during long-term multiplication in the intestinal tract.
一名患有丙种球蛋白血症的3岁男孩在接种脊髓灰质炎疫苗553天后患上了麻痹性脊髓灰质炎。在发病后684天内采集的22份粪便样本中分离出了非疫苗株2型脊髓灰质炎病毒。这些病毒之间存在抗原变异。在瘫痪发作1周后分离出的非疫苗株病毒在猴子神经毒力试验中的毒力与萨宾2型疫苗株不同，并且与野生强毒株没有相同的抗原特性。在发病前348天分离出的另一种病毒也被归类为非疫苗株。然而，通过麦克布赖德试验表明萨宾2型毒株与该毒株同源。在这种储备病毒中发现了一些类似萨宾株的颗粒。我们可以得出结论，非疫苗株病毒分离物是在肠道中长期繁殖过程中通过抗原变异从萨宾疫苗衍生而来的。
