胍法辛的药理学
Pharmacology of guanfacine.
作者信息
Scholtysik G
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):21S-24S. doi: 10.1111/j.1365-2125.1980.tb04900.x.
Abstract
- The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose-dependently after oral application of 0.3-5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.
摘要
- 对中枢性抗高血压药物胍法辛的药理作用进行了综述。2. 口服0.3 - 5毫克/千克后，该药物能使高血压大鼠的全身血压呈剂量依赖性降低。3. 有证据表明胍法辛通过特异性刺激中枢α-肾上腺素能受体产生其抗高血压作用。4. 讨论了可乐定和胍法辛之间的某些药理差异。
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