可乐定的中枢心血管作用定位
Localization of the central cardiovascular action of clonidine.
作者信息
Bousquet P, Guertzenstein P G
出版信息
Br J Pharmacol. 1973 Dec;49(4):573-9. doi: 10.1111/j.1476-5381.1973.tb08532.x.
Abstract
- The fall in arterial blood pressure with bradycardia that occurs on injection of clonidine into the cerebral ventricles and into the cisterna magna is attributed to an action on ;chemosensitive zones' situated at the ventral surface of the brain stem. This conclusion is based on the following results obtained in cats anaesthetized with pentobarbitone sodium.2. The fall in blood pressure no longer occurs on injection of clonidine (10 to 100 mug) into the cerebral ventricles when the passage of clonidine into the subarachnoid space is prevented by cannulation of the aqueduct. In this condition, the injections produce instead a rise in blood pressure.3. Applied bilaterally, by means of perspex rings, to the ventral surface of the brain stem, clonidine (10 mul of a 50 to 1,000 mug/ml solution placed in each ring) produces a fall in blood pressure with bradycardia, but only when the perspex rings cover the ;chemosensitive zones' from which changes in blood pressure and heart rate are obtained with various drugs.
摘要
向脑室和小脑延髓池注射可乐定时出现的动脉血压下降伴心动过缓，归因于对位于脑干腹面的“化学敏感区”的作用。该结论基于在用戊巴比妥钠麻醉的猫身上获得的以下结果。
当通过插管导水管阻止可乐定进入蛛网膜下腔时，向脑室注射可乐定（10至100微克）后血压不再下降。在这种情况下，注射反而会使血压升高。
通过有机玻璃环双侧施加于脑干腹面，可乐定（将50至1000微克/毫升溶液10微升置于每个环中）会导致血压下降伴心动过缓，但仅当有机玻璃环覆盖“化学敏感区”时才会如此，通过各种药物可从此处获得血压和心率的变化。
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