大肠杆菌RNA聚合酶与禽肉瘤病毒基因组3'端附近的特定位点的结合。
Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome.
作者信息
Guntaka R V, Rao P Y, Katz R A, Mitsialis S A
出版信息
Biochim Biophys Acta. 1980 May 30;607(3):457-69. doi: 10.1016/0005-2787(80)90156-2.
PMID:6249369
Abstract
We have isolated a unique 35 base pair region of avian tumor virus DNA that binds specifically to Escherichia coli RNA polymerase holoenzyme. Studies with various size classes of viral DNA coupled with restriction enzyme mapping data indicate that the binding site is located in the large terminal repeat of the viral genome and is within the first 50 nucleotides of the heteropolymeric region corresponding to the 3'-end of the virion RNA.
摘要
我们已经分离出禽肿瘤病毒DNA的一个独特的35个碱基对区域，它能特异性结合大肠杆菌RNA聚合酶全酶。对不同大小类别的病毒DNA进行的研究以及限制性内切酶图谱数据表明，结合位点位于病毒基因组的大末端重复序列中，并且在与病毒粒子RNA 3'-末端相对应的异聚区域的前50个核苷酸内。
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