鼠白血病病毒长末端重复序列中的一个独特序列可作为大肠杆菌中转录的终止信号。
A unique sequence in murine leukemia virus long terminal repeat functions as a termination signal for transcription in Escherichia coli.
作者信息
Honigman A, Panet A
出版信息
J Virol. 1983 Jan;45(1):456-61. doi: 10.1128/JVI.45.1.456-461.1983.
Abstract
Moloney murine leukemia virus DNA fragments were subcloned into two plasmids downstream of active promoters to detect termination sequences for transcription initiated at these promoters. Two of the viral DNA fragments (2,050 and 595 base pairs) were able to block transcription when inserted in one orientation but not when inserted in the other. These two viral DNA fragments contained long terminal repeat sequences. Deletion of 84 base pairs from the U-3 and R regions in the long terminal repeat removed the transcription termination activity.
摘要
莫洛尼鼠白血病病毒DNA片段被亚克隆到两个质粒中，位于活性启动子下游，以检测从这些启动子起始转录的终止序列。两个病毒DNA片段（2050和595个碱基对）以一种方向插入时能够阻断转录，但以另一种方向插入时则不能。这两个病毒DNA片段含有长末端重复序列。从长末端重复序列的U-3和R区域缺失84个碱基对消除了转录终止活性。
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