Lee D A, Rao B R, Meyer J S, Prioleau P G, Bauer W C
Cancer. 1980 Aug 1;46(3):547-51. doi: 10.1002/1097-0142(19800801)46:3<547::aid-cncr2820460321>3.0.co;2-s.
Juvenile nasopharyngeal angiofibromas (JNA) are rare. They have been frequently treated with estrogens, either solely or as an adjuvant therapy prior to surgery or irradiation. Clinical trials have proveded no evidence to explain the objective respose to estrogens observed in some tumors. Since the mechanism of steroid hormone action is mediated via specific receptors, we analyzed 8 JNA for tumor cytosol estrogen receptors. None were positive for estrogen receptors. Additionally, all were also negative for progesterone receptors. Nasopharyngeal angiofibromas occur predominantly in adolescent boys at a time when there is a gradual change in androgen availability. Therefore, three latter angiofibromas were also analyzed for the presence of cytosol androgen receptor. Specific testosterone and dihydrotestosterone binding components in the tumor cytosol were detected. This observation raises for the first time the possibility that JNA may be an androgen-dependent tumor. Estrogen may act as an antiandrogen on these tumors, an action similar to that on prostate cancer.
青少年鼻咽血管纤维瘤（JNA）较为罕见。过去常使用雌激素对其进行治疗，单独使用或在手术或放疗前作为辅助治疗。临床试验并未提供证据来解释在某些肿瘤中观察到的对雌激素的客观反应。由于类固醇激素作用的机制是通过特定受体介导的，我们分析了8例青少年鼻咽血管纤维瘤的肿瘤细胞溶质雌激素受体。无一例雌激素受体呈阳性。此外，所有病例的孕激素受体也均为阴性。鼻咽血管纤维瘤主要发生于青春期男孩，此时雄激素的可利用性会逐渐发生变化。因此，我们还分析了后3例血管纤维瘤的细胞溶质雄激素受体的存在情况。在肿瘤细胞溶质中检测到了特异性睾酮和双氢睾酮结合成分。这一观察首次提出了青少年鼻咽血管纤维瘤可能是雄激素依赖性肿瘤的可能性。雌激素可能对这些肿瘤起抗雄激素作用，这一作用与对前列腺癌的作用类似。
