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人乳腺癌中纤连蛋白的缺失

Loss of fibronectin in human breast cancer.

作者信息

Labat-Robert J, Birembaut P, Adnet J J, Mercantini F, Robert L

出版信息

Cell Biol Int Rep. 1980 Jun;4(6):609-16. doi: 10.1016/0309-1651(80)90028-4.

DOI:10.1016/0309-1651(80)90028-4
PMID:6249503
Abstract

The distribution of fibronectin was studied in normal human breast tissue and in breast tumors. In normal tissues and in benign tumors, fibronectin was present in basal laminae and on the cellular surfaces of myoepithelial and secretory cells. A partial loss of (pericellular) fibronectin was seen in atypical dystrophies, and a complete disappearance of pericellular and basement membrane-bound fibronectin was observed in invasive adenocarcinoma.

摘要

研究了纤连蛋白在正常人类乳腺组织和乳腺肿瘤中的分布。在正常组织和良性肿瘤中,纤连蛋白存在于基底膜以及肌上皮细胞和分泌细胞的细胞表面。在非典型营养不良中可见(细胞周围的)纤连蛋白部分缺失,而在浸润性腺癌中观察到细胞周围和基底膜结合的纤连蛋白完全消失。

相似文献

1
Loss of fibronectin in human breast cancer.人乳腺癌中纤连蛋白的缺失
Cell Biol Int Rep. 1980 Jun;4(6):609-16. doi: 10.1016/0309-1651(80)90028-4.
2
Immunohistochemical localization of myoepithelial cells and basement membrane in normal, benign and malignant human breast lesions.人正常、良性及恶性乳腺病变中肌上皮细胞和基底膜的免疫组织化学定位
Virchows Arch A Pathol Anat Histopathol. 1988;413(2):133-9. doi: 10.1007/BF00749674.
3
Distribution of oncofetal fibronectin in human mammary tumors: immunofluorescence study on histological sections.癌胚纤连蛋白在人乳腺肿瘤中的分布:组织切片的免疫荧光研究
Cancer Res. 1990 Mar 1;50(5):1608-12.
4
Immunohistochemical localization of S100 protein in benign and malignant conditions of the breast.
Arch Pathol Lab Med. 1987 Jan;111(1):28-31.
5
Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane.利用抗豚鼠乳脂肪球膜单克隆抗体对人乳腺良性纤维囊性疾病和浸润性导管癌中一种膜糖蛋白进行定位。
Am J Pathol. 1985 Mar;118(3):351-9.
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[Immunolocalization of laminin, fibronectin, and collagens I to V in the normal and mastotic breast].[层粘连蛋白、纤连蛋白以及Ⅰ至Ⅴ型胶原蛋白在正常乳腺和乳腺肥大组织中的免疫定位]
J Gynecol Obstet Biol Reprod (Paris). 1982;11(5):549-54.
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引用本文的文献

1
[Fibronectin].[纤连蛋白]
Klin Wochenschr. 1984 Oct 15;62(20):963-74. doi: 10.1007/BF01728426.
2
Heterogeneous distribution of actin, myosin, fibronectin and basement membrane antigens in primary and metastatic human breast cancer.肌动蛋白、肌球蛋白、纤连蛋白和基底膜抗原在原发性和转移性人类乳腺癌中的异质性分布。
Virchows Arch A Pathol Anat Histopathol. 1984;405(1):69-83. doi: 10.1007/BF00694926.
3
In vivo demonstration of cytoplasmic fibronectin in human breast carcinomas.人乳腺癌中细胞质纤连蛋白的体内证明
Virchows Arch A Pathol Anat Histopathol. 1985;407(3):337-46. doi: 10.1007/BF00710658.
4
Immunocytochemistry of intracranial meningiomas.颅内脑膜瘤的免疫细胞化学
J Neurooncol. 1987;5(4):357-68. doi: 10.1007/BF00148393.
5
Pattern of fibronectin distribution in human lung cancer.纤连蛋白在人肺癌中的分布模式。
J Cancer Res Clin Oncol. 1986;112(1):1-5. doi: 10.1007/BF00394930.
6
Differentiation between metaplastic carcinomas and sarcomas of the human female breast by fibronectin.通过纤连蛋白对人类女性乳腺化生癌和肉瘤进行鉴别
Virchows Arch A Pathol Anat Histopathol. 1985;407(4):465-76. doi: 10.1007/BF00709993.
7
The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes.纤连蛋白在淋巴结转移性肿瘤生长过程中的早期出现。
J Cancer Res Clin Oncol. 1985;109(1):65-71. doi: 10.1007/BF01884257.
8
Immunohistochemical study of fibronectin, lysozyme, and alpha-fetoprotein (AFP) in human hepatocellular carcinoma.人肝细胞癌中纤连蛋白、溶菌酶和甲胎蛋白(AFP)的免疫组织化学研究
Gastroenterol Jpn. 1987 Feb;22(1):44-54. doi: 10.1007/BF02806334.