Klar E, Heene D L
Klin Wochenschr. 1984 Oct 15;62(20):963-74. doi: 10.1007/BF01728426.
Fibronectin is a dimeric glycoprotein with a molecular weight of 440,000. It is a soluble constituent of plasma and other body fluids and a fibrillar matrix protein of connective tissue. The two components are structurally similar and convertible. The possibility of multiple molecular interactions gives rise to a variety of biological functions. The regulation of cell growth and the reduced shedding of fibronectin from malignant cells raises the question as to whether fibronectin is valid as a tumour marker. In wound healing and chronic inflammation fibronectin serves as a scaffold for the formation of collagen. As opsonic protein it maintains reticuloendothelial function. Especially in shock, fibronectin may become the limiting factor of unspecific host defence mechanisms. The value of a substitution therapy will be discussed.
纤连蛋白是一种分子量为440,000的二聚体糖蛋白。它是血浆和其他体液的可溶性成分，也是结缔组织的纤维状基质蛋白。这两种成分在结构上相似且可相互转换。多种分子相互作用的可能性产生了多种生物学功能。细胞生长的调节以及恶性细胞中纤连蛋白脱落的减少引发了关于纤连蛋白作为肿瘤标志物是否有效的问题。在伤口愈合和慢性炎症中，纤连蛋白作为胶原蛋白形成的支架。作为调理蛋白，它维持网状内皮系统的功能。特别是在休克时，纤连蛋白可能成为非特异性宿主防御机制的限制因素。将讨论替代疗法的价值。
