Seino Y, Shimotsuji T, Ishida M, Ishii T, Yamaoka K, Yabuuchi H
Contrib Nephrol. 1980;22:101-6. doi: 10.1159/000385992.
Plasma levels of 1,25-(OH)2-D were low in children with hypophosphatemic vitamin D-resistant rickets (HVDRR), but increased after very large doses of 1 alpha-OH-D3. These results suggest that the metabolism of 1,25-(OH)2-D is accelerated in HVDRR. In addition, the lower level of plasma 1,25-(OH)2-D in untreated HVDRR was correlated with the lower level of serum phosphate and renal threshold phosphate concentration (TmP/GFR). The administration of 1 alpha-OH-D3 to the patients with HVDRR could enhance the renal threshold phosphate concentration.
低磷抗维生素D佝偻病（HVDRR）患儿的血浆1,25-(OH)2-D水平较低，但在给予非常大剂量的1α-OH-D3后升高。这些结果表明，HVDRR中1,25-(OH)2-D的代谢加速。此外，未经治疗的HVDRR患者血浆1,25-(OH)2-D水平较低与血清磷酸盐水平较低及肾磷酸盐阈浓度（TmP/GFR）有关。给HVDRR患者服用1α-OH-D3可提高肾磷酸盐阈浓度。
