Steele R W, Marmer D J, Keeney R E
Infect Immun. 1980 Jun;28(3):957-62. doi: 10.1128/iai.28.3.957-962.1980.
In vitro lymphocyte blastogenic responses to the commonly employed mitogens phytohemagglutinin, pokeweed, and concanavalin A were evaluated when acyclovir, adenine arabinoside, cytosine arabinoside, and idoxuridine were added to the culture materials. Similarly, specific antigen-induced blastogenic responses, including herpes group antigens, and cytotoxicity and leukocyte inhibitory factor assays with herpes group viruses were determined in the presence and absence of antiviral agents. No depression of these cellular immmune responses by acyclovir or adenine arabinoside ws demonstrated. This was in contrast to the effects of cytosine arabinoside and idoxuridine, which severely inhibited blastogenic and cytotoxic responses but not leukocyte inhibitory factor production. Even at concentrations up to 20 microgram/ml, the antiviral agent acyclovir did not depress selected cellular immune responses that are important for successful elimination of invading herpes group viruses.
当将阿昔洛韦、阿糖腺苷、阿糖胞苷和碘苷添加到培养基中时，评估了体外淋巴细胞对常用有丝分裂原植物血凝素、商陆和刀豆球蛋白A的增殖反应。同样，在有和没有抗病毒药物的情况下，测定了包括疱疹病毒组抗原在内的特异性抗原诱导的增殖反应，以及疱疹病毒组病毒的细胞毒性和白细胞抑制因子测定。未证明阿昔洛韦或阿糖腺苷会抑制这些细胞免疫反应。这与阿糖胞苷和碘苷的作用形成对比，后者严重抑制增殖和细胞毒性反应，但不抑制白细胞抑制因子的产生。即使在浓度高达20微克/毫升时，抗病毒药物阿昔洛韦也不会抑制对成功清除入侵的疱疹病毒组病毒很重要的特定细胞免疫反应。
