阿昔洛韦预防单纯疱疹病毒感染。
Acyclovir prophylaxis for herpes simplex virus infection.
作者信息
Gold D, Corey L
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):361-7. doi: 10.1128/AAC.31.3.361.
Abstract
ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction chemotherapy should be screened routinely for HSV antibodies; seropositive individuals should receive prophylactic ACV during the period of most profound immunosuppression. Immunologically normal individuals with frequently recurring genital HSV or serious complications associated with outbreaks are candidates for long-term suppression with ACV.
摘要
阿昔洛韦（ACV）是治疗和预防免疫受损（IC）个体及免疫正常个体单纯疱疹病毒（HSV）感染的有效药物。该药物在这两类人群中耐受性良好，且与临床或实验室毒性无显著关联。鉴于其巨大的潜在益处和低风险，器官移植受者及接受诱导化疗的血液系统恶性肿瘤患者应常规筛查HSV抗体；血清学阳性个体应在免疫抑制最严重期间接受阿昔洛韦预防性治疗。频繁复发生殖器HSV或与发作相关严重并发症的免疫正常个体是阿昔洛韦长期抑制治疗的候选对象。
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