Bahna M S, Ward P H, Konrad H R
Otolaryngol Head Neck Surg (1979). 1980 Mar-Apr;88(2):146-53. doi: 10.1177/019459988008800209.
Rhinocerebral mucormycosis, a highly lethal fungal infection of the head and neck, is commonly recognized by its classic appearance. Two cases of this newly recognized clinical syndrome with isolated unilateral peripheral cranial nerve V, VI, VII, IX, X, XI, and XII palsies and initial sparing of the eighth cranial nerve are presented. Examination revealed that each patient had ulceration of the nasopharynx and osteitis of the base of the skull. Nose, orbits, paranasal sinuses, and intracranial nervous systems were initially spared. The cause of this obscure cranial nerve paralysis was diagnosed from biopsy specimens of the nasopharyngeal tissues and the demonstration of nonseptate hyphae. Review of the literature did not indicate that this syndrome had previously been recognized. The name nasopharyngeal mucormycotic osteitis is suggested.
鼻脑型毛霉菌病是一种头颈部高度致命的真菌感染，通常以其典型表现而被识别。本文报告了两例这种新认识的临床综合征，表现为孤立的单侧外周颅神经Ⅴ、Ⅵ、Ⅶ、Ⅸ、Ⅹ、Ⅺ和Ⅻ麻痹，且第八颅神经最初未受累。检查发现，每位患者均有鼻咽部溃疡和颅底骨炎。鼻、眼眶、鼻窦和颅内神经系统最初未受累。通过鼻咽组织活检标本及非分隔菌丝的显示，诊断出这种不明原因的颅神经麻痹的病因。文献回顾未表明此前已认识到这种综合征。建议将其命名为鼻咽部毛霉菌性骨炎。
