Kalin N H, Risch S C, Cohen R M, Insel T, Murphy D L
Science. 1980 Aug 15;209(4458):827-8. doi: 10.1126/science.6250217.
In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.
在人类和恒河猴中，地塞米松降低了血浆皮质醇的浓度，但并未改变循环中的β-内啡肽免疫反应性。当前理论认为垂体β-内啡肽和促肾上腺皮质激素受相同的合成和释放调节机制控制，然而与该理论相反，我们的证据表明，在高等灵长类动物中，促肾上腺皮质激素 - 皮质醇系统已确立的糖皮质激素反馈机制对β-内啡肽分泌的调节方式并不相同。
