Gelfand E W, Cheung R, Hastings D, Dosch H M
Adv Exp Med Biol. 1980;127:429-46. doi: 10.1007/978-1-4757-0259-0_34.
Cell surface receptors receive, transduce and relay a variety of environmental signals. These phenomena, which have been extensively characterized in non-lymphoid cells, also appear to play a crucial role in dictating the degree of lymphocyte responsiveness. The nature of these regulatory events is only beginning to be unraveled but the adenylate cyclase-cyclic AMP axis appears to be one of the important controlling systems. Lithium appears to be as important a modulator of lymphocyte responsiveness as previously shown for a variety of other cells and the mechanism of action, in general, is consistent with its role as a putative blocker of adenylate cyclase activation. Indeed, lithium may exert its role as a regulator of lymphocyte responsiveness by acting on specific lymphocyte subpopulations. Direct proof for this is still wanting and consideration of its capacity for action as an imperfect substitute for normal extra- or intracellular cations or on the physiochemical state of the plasma membrane is necessary. Nevertheless, these studies indicate the validity of using lithium for assessing the role of the lymphocyte adenylate cyclase-cyclic AMP system in the generation and expression of regulatory signals leading to modulation of the immune system.
细胞表面受体接收、转导并传递各种环境信号。这些现象在非淋巴细胞中已得到广泛表征，似乎在决定淋巴细胞反应程度方面也起着关键作用。这些调节事件的本质才刚刚开始被揭示，但腺苷酸环化酶 - 环磷酸腺苷轴似乎是重要的控制系统之一。锂似乎是淋巴细胞反应性的重要调节剂，就像之前在多种其他细胞中所显示的那样，其作用机制总体上与其作为腺苷酸环化酶激活假定阻滞剂的作用一致。实际上，锂可能通过作用于特定的淋巴细胞亚群来发挥其作为淋巴细胞反应性调节剂的作用。对此的直接证据仍然缺乏，并且有必要考虑其作为正常细胞外或细胞内阳离子的不完美替代物的作用能力，或者其对质膜物理化学状态的影响。然而，这些研究表明使用锂来评估淋巴细胞腺苷酸环化酶 - 环磷酸腺苷系统在导致免疫系统调节的调节信号的产生和表达中的作用是有效的。
