Gelfand E W, Dosch H M, Hastings B, Shore A
Science. 1979 Jan 26;203(4378):365-7. doi: 10.1126/science.216075.
Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.
茶碱、沙丁胺醇、异丙肾上腺素和二丁酰环磷腺苷抑制了三名无丙种球蛋白血症患者的人T淋巴细胞形成E玫瑰花结以及人空斑形成B细胞分泌免疫球蛋白M，并增强了T抑制细胞活性。氯化锂增加了有丝分裂原诱导的淋巴细胞增殖并抑制了抑制细胞活性。在锂存在的情况下，除二丁酰环磷腺苷外的所有药物的作用都可以被阻止。这些数据表明锂在调节淋巴细胞中环磷腺苷依赖性事件中起作用。其作为抑制细胞活性抑制剂的潜在作用值得进一步关注。
