Sharma J M, Lee L F, Witter R L
Am J Vet Res. 1980 May;41(5):761-4.
Effect of immunosuppression on pathogenicity of herpesvirus of turkeys (HVT) in chickens was studied. In three experiments, newly hatched chickens of two genetic strains were surgically thymectmized and gamma-irradiated and then exposed to HVT. Lymphoid cells of thymectomized-irradiated chickens had reduced in vitro mitogenic response; this result indicated that the immunosuppressive regimen caused suppression of T cell function. The immunosuppressed chickens had more circulating HVT and had a slightly higher frequency of microsocpic lesions in peripheral nerves than the intact control chickens, although the intensity of lymphoproliferation remained very mild and no gross lesions or clinical disease was noted during the 5-week observation period. The absence of significant lesion development in an immunosuppressed host indicated that pathogenic potentials of HVT may be limited.
研究了免疫抑制对火鸡疱疹病毒（HVT）在鸡体内致病性的影响。在三个实验中，对两个遗传品系的新孵出的鸡进行手术切除胸腺并进行γ射线照射，然后使其接触HVT。经胸腺切除-照射的鸡的淋巴细胞体外促有丝分裂反应降低；这一结果表明免疫抑制方案导致T细胞功能受到抑制。与完整对照鸡相比，免疫抑制鸡体内循环的HVT更多，外周神经微观病变的频率略高，尽管在5周的观察期内淋巴增殖的强度仍然非常轻微，未观察到明显病变或临床疾病。免疫抑制宿主中未出现明显病变发展，这表明HVT的致病潜力可能有限。
