Wutzler P, Sprössig M, Hirsch J, Brichaćek B, Vonka V, Schindler E, Wutke K, Rüdiger K D, Wöckel W
Dtsch Med Wochenschr. 1980 Jul 4;105(27):961-6. doi: 10.1055/s-2008-1070792.
A 6-year-old European boy with a tumour in the head and neck region died 86 days after the first occurrence of symptoms despite chemo- and radiotherapy. An epipharyngeal biopsy at the beginning of the disease and a cytological investigation of biopsy and autopsy material showed non-Hodgkin lymphoma with a high degree of malignancy of the Burkitt type. High antibody titres against Epstein-Barr virus (EBV)-specific virus capsid antigen, nuclear antigen and the R component of the EBV-early-antigen-complex as well as the approximately 27 EBV genome equivalents per tumour cell, demonstrated by DNA-DNA hybridisation, characterised the tumour as true Burkitt lymphoma which is observed extremely seldom outside Africa.
一名6岁欧洲男孩,头颈部患有肿瘤,尽管接受了化疗和放疗,但在首次出现症状86天后死亡。疾病初期的咽上活检以及活检和尸检材料的细胞学检查显示为非霍奇金淋巴瘤,属于高度恶性的伯基特型。通过DNA-DNA杂交证实,针对爱泼斯坦-巴尔病毒(EBV)特异性病毒衣壳抗原、核抗原以及EBV早期抗原复合物的R成分的抗体滴度很高,并且每个肿瘤细胞约有27个EBV基因组当量,这些特征表明该肿瘤为真正的伯基特淋巴瘤,这种淋巴瘤在非洲以外地区极为罕见。